Le sildénafil présente une absorption digestive influencée par l’alimentation, particulièrement par les repas riches en graisses qui retardent l’apparition de la concentration maximale. La biodisponibilité absolue avoisine 40 %, avec une liaison protéique élevée. Son mécanisme repose sur l’inhibition de la PDE5, conduisant à une élévation du GMPc intracellulaire et à une relaxation musculaire lisse transitoire. Le métabolisme est hépatique, sous l’action du CYP3A4 principalement. L’élimination se fait par voie biliaire et urinaire. Des interactions pharmacologiques sont décrites avec nitrates organiques, générant un risque de chute tensionnelle marquée. Les descriptions techniques associent prix viagra générique aux profils pharmacocinétiques courts et aux caractéristiques enzymatiques particulières de la molécule.

The Mystery Train gets a dose of intrigue with an interactive murder mystery show. The price of your ticket includes the three-hour train ride, four courses of American fare with unlimited coffee and soft drinks, and fun and immersive dinner theatre.

As the train rolls along, you’ll meet a cast of quirky characters who will draw you into their drama as they squabble, scheme, and ultimately kill each other. We’ll be counting on you to solve the case while you dine.

Event starts at 5:00 pm.  Price is $89 per person.  Details on driving as a group will be discussed at the next meeting.

Dinner Menu*

Start your evening with a shrimp cocktail.

Continue the meal with soup or salad. Our chef will choose the perfect compliment for the meal and the season. (Most dinner trips occurring in the winter will feature soup.)

Choose from the following entrée selections:

  • Beef Tenderloin Medallion: Twin 3 oz. beef tenderloin medallions served with mashed potatoes and topped with portobello mushrooms, tomatoes, smoked bacon mixture, and finished with gorgonzola crumbles and a light au jus sauce.
  • Mediterranean Chicken: Seared chicken breast topped with sun dried tomatoes, artichoke hearts, olives, button mushrooms, and finished with feta cheese crumbles, balsamic syrup and basil oil. Served with mashed potatoes.
  • Seared Salmon: Pan-seared salmon is served atop a bed of rice pilaf, finished with a basil-dill cream sauce.
  • Garden Lasagna: Vegetarian lasagna layered with fresh garden veggies in a spicy marinara.